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Human Reproduction, Vol. 9, No. 2, pp. 241-244, 1994
© 1994 European Society of Human Reproduction and Embryology

other

Effect of follicle stimulating hormone treatment on the pituitary response to luteinizing hormone-releasing hormone in post-menopausal women

I.E. Messinis3, D. Lolis, L. Papastergiopoulou, S. Milingos, E. Tsahalina1, K. Seferiadis1 and A.A. Templeton2

Department of Biological Chemistry, University of loannina 45332 loannina, Greece 1Department of Obstetrics and Gynaecology, University of Aberdeen Foresterhill, Aberdeen AB9 2ZD, UK 2Department of Obstetrics and Gynaecology University of Aberdeen 45332 loannina, Greece

Correspondence: 3To whom correspondence should be addressed

To study the role of exogenous follicle stimulating hormone (FSH) in the attenuation of luteinizing hormone (LH) response to luteinizing hormone-releasing hormone (LHRH) during ovulation induction in women, 10 healthy post-menopausal women were treated with FSH (225 IU/day) for 5 days and normal saline (2 ml/day) for another 5 days. The two regimens were given consecutively in a 10 day experiment. The regimen for the first 5 days was randomly chosen and was given to the women in an alternate way. The response of LH to an i.v. injection of 10 µg LHRH was investigated twice on day 1 (i.e. before the onset of treatment and 12 h later) and once on days 2, 5 and 10 of the experiment (0900 h). Basal FSH and LH values before the onset of treatment on day 1 were similar in the five women who started with the saline and the five who started with the FSH regimen. Basal FSH values increased significantly during treatment with FSH, while LH and oestradiol values remained unchanged throught the whole experiment. LH increment 30 min post –LHRH did not change significantly either during the first 24 h or during the whole experiment regardless of the starting regimen. These results demonstrate that in post-menopausal women the response of LH to LHRH is not affected by exogenous administration of FSH. It is suggested that exogenous FSH does not show activities on gonadotrophin secretion similar to those ascribed to a gonadotrophin secretion similar to those ascribed to a gonadotrophin surge attenuating factor.

Key words: FSH/GnSAF/human/LH/LHRH


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