Human Reproduction, Vol. 9, No. 2, pp. 253-258, 1994
© 1994 European Society of Human Reproduction and Embryology
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Progesterone control of interleukin-8 production in endometrium and chorio-decidual cells underlines the role of the neutrophil in menstruation and parturition
Medical Research Council Reproductive Biology Unit 37 Chalmers Street, Edinburgh EH3 9EW, UK 2Department of Obstetrics and Gvnaecology, University of Edinburgh Centre for Reproductive Biology 37 Chalmers Street, Edinburgh EH3 9EW, UK
Correspondence: 1To whom correspondence should be addressed
Interleukin-8 (IL-8) attracts neutrophils into tissues and caused them to degtranulate. Both menstruation and parturition involve neutrophil migration into uterine tissues and therefore IL-8 is a likely mediator of the tissue re-arrangements that accompany these events. We have examined the ability of endometrium explants and chorion cells in culture to synthesize and release IL-8 and the ability of progesterone, a sunthetic progestin[medroxyprogesterone acetate(MPA)] and dexamethasone to inhibit this production. In endo-metrium, the stage of the menstrual cycle didnot affect IL-8 production but a 10–6 M concentration of progesterone or dexamethasone significantly reduced the concentration of IL-8 in medium after 24 H. After a further 24 h with lipopoly-saccharide (LPS) stimulation, only MPA and dexamethasone inhibited production significantly. In chorion cells, IL-8 production was significantly decreased by both MPA and dexamethasone in the LPS stimulated cells but the reduction in the first 24 h was not significant. The IL-8 produced in uterine tissues might act synergistically with prostaglandin E (PGE), a likely site for this interaction being blood vessels where PGE production is also repressed by progesterone. Such a co-operative action would maintain low leykocyte entry into uterine tissues in the presence of progesterone and falling steroid levels would induce leukocyte immigration and activation with consequent tissue destruction. Such steroid-dependent interactions are important in our understanding of the mechanisms of menstruation and paturition and could allow new approaches to the treatment of uterine pathology.
Key words: interleykin-8/menstruation/neutrophil/parturition/progesterone
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