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Human Reproduction, Vol. 9, No. 4, pp. 643-645, 1994
© 1994 European Society of Human Reproduction and Embryology

other

Immunity to zona pellucida in women with low response to ovarian stimulation, in unexplained infertility and after multiple IVF attempts

Yedidya Hovav, Miriam Almagor1, Dalit Benbenishti, Ehud J. Margalioth, Irit Kafka and Haim Yaffe

Department of Obstetrics and Gynaecology, Bikur Cholim Hospital 5 Strauss Street, Jerusalem, Israel

Correspondence: 1To whom correspondence should be addressed

A retrospective study was designed to assess the presence of antizona pellucida autoantibodies in in-vitro fertilization (IVF) patients in relation to low ovarian response, multiple IVF attempts and unexplained infertility. Antizona pellucida and antisperm antibodies were determined in serum samples obtained from 37 women undergoing IVF-embryo transfer and 20 fertile women. Antizona pellucida antibodies were measured using enzyme immunoabsorbent assay. Antisperm antibodies were evaluated by the immunobead binding method. Three of 10 patients with low response to ovarian stimulation had antizona pellucida antibodies in serum and one patient had antisperm antibodies. None of the other participants in the study and the control groups demonstrated measurable levels of serum antigamete antibodies. The results in this small group suggest an association between antizonapellucida antibodies and suboptimal response to gonadotrophins. It is indicated that repeated stimulation and puncture of ovaries in IVF procedures do not elicit auto-immunity to gametes.

Key words: antisperm antibodies/antizona pellucida antibodies/IVF/low ovarian response


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