Skip Navigation

This Article
Right arrow Full Text (PDF )
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (37)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Klentzeris, L.D.
Right arrow Articles by Cooke, I.D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Klentzeris, L.D.
Right arrow Articles by Cooke, I.D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 9, No. 4, pp. 646-652, 1994
© 1994 European Society of Human Reproduction and Embryology

other

Lymphoid tissue in the endometrium of women with unexplained infertility: morphometric and immunohistochemical aspects

L.D. Klentzeris1,5, J.N. Bulmer2, M.A. Warren3, L. Morrison4, T.C. Li1 and I.D. Cooke1

1University Department of Obstetrics and Gynaecology, Jessop Hospital for Women Sheffield S3 7RE, UK 2Division of Pathology, School of Pathological Sciences, University of Newcastle upon Tyne NE1 4LP Leeds LS2 9JT, UK 3Department of Biomedical Science, University of Sheffield Sheffield S10 2TN, UK 4Academic Unit of Pathology, University of Leeds Leeds LS2 9JT, UK

Correspondence: 5To whom correspondence should be addressed at: Academic Department of Obstetrics and Gynaecology, Floor D, Queen's Medical Centre, Nottingham NG7 2UH, UK

The purpose of this study was to investigate whether the endometrium of women with unexplained infertility differs in some immunological aspects from the endometrium of normal fertile women. Endometrial biopsies were obtained from 24 normal fertile women (group I) and 24 women suffering from unexplained infertility (group II) at 4, 7, 10 and 13 days following the luteinizing hormone (LH) surge. Endometrial granulated lymphocytes were assessed morphometrically in 2µm resin sections. A panel of 11 monoclonal antibodies was employed to characterize the leukocyte subsets in frozen sections. Semi-quantification was performed with a Quantimet 970 image analyser. Data were analysed using one-and two-way analysis of variance. Compared with fertile controls, women with unexplained infertility had significantly lower numbers of CD8+ (T suppressor/cytotoxic) cells at each post-LH date. In contrast, the number of CD4+ (T helper/inducer) cells was significantly higher in group II. Throughout the luteal phase, infertile women had fewer CD56+ cells than normal fertile controls. The volume fraction of endometrium occupied by the nuclei of endometrial granulated lymphocytes did not alter with the cycle stage but the mean nuclear diameter and axial ratio decreased from LH+7 to LH+13. The differences observed in endometrial leukocytic subpopulations between fertile and infertile women may contribute to unexplained infertility probably by affecting the embryonic maternal dialogue during the implantation and early placentation period.

Key words: endometrium/infertile/leukocytes


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
P. J. Scaife, J. N. Bulmer, S. C. Robson, B. A. Innes, and R. F. Searle
Effector Activity of Decidual CD8+ T Lymphocytes in Early Human Pregnancy
Biol Reprod, October 1, 2006; 75(4): 562 - 567.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. Garzia, S. Borgato, V. Cozzi, P. Doi, G. Bulfamante, L. Persani, and I. Cetin
Lack of expression of endometrial prolactin in early implantation failure: a pilot study
Hum. Reprod., August 1, 2004; 19(8): 1911 - 1916.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. C. Quack, N. Vassiliadou, J. Pudney, D. J. Anderson, and J. A. Hill
Leukocyte activation in the decidua of chromosomally normal and abnormal fetuses from women with recurrent abortion
Hum. Reprod., May 1, 2001; 16(5): 949 - 955.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
M.v. Wolff, C.J. Thaler, T. Strowitzki, J. Broome, W. Stolz, and S. Tabibzadeh
Regulated expression of cytokines in human endometrium throughout the menstrual cycle: dysregulation in habitual abortion
Mol. Hum. Reprod., July 1, 2000; 6(7): 627 - 634.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. Clifford, A.M. Flanagan, and L. Regan
Endometrial CD56+ natural killer cells in women with recurrent miscarriage: a histomorphometric study
Hum. Reprod., November 1, 1999; 14(11): 2727 - 2730.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.