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Human Reproduction, Vol. 9, No. 5, pp. 772-780, 1994
© 1994 European Society of Human Reproduction and Embryology

other

Effects of persistent chlorinated hydrocarbons on reproductive tissues in female rabbits

Antje Lindenau2, Bernd Fischer2, Petra Seiler1 and Henning M. Beier1

1Department of Anatomy and Reproductive Biology, Medical Faculty, RWTH University of Aachen D Aachen, Germany

The female rabbit was used to study (i) accumulation of lipophilic chlorinated hydrocarbons in genital tract tissues and (ii) subsequent morphological and functional effects after longterm low-dose exposure. Polychlorinated biphenyl (PCB), 1 ,1-dl(p-chlorophenyl)-2,2,2-trichloroethane (DDT) and {gamma}-hexachlorocyciohexane ({gamma}-HCH) (dosages: 4,3 and 0.8 mg per kg body weight, respectively) and a combination of these three components (and dosages) were administered to sexually mature rabbits over a period of 12–15 weeks. The animals were killed shortly before and at various times after ovulatioii. Accumulation of chlorinated hydrocarbons was high in ovarian, oviductal and uterine tissues, in follicular fluid and clearly detectable in uterine secretions. In follicular fluid, the concentration and patterns of congeners and isomers of PCB and DDT were distinctly different from serum. DDT-and {gamma}-HCH-treated animals showed a significantly reduced ovulation rate (P < 0.002 and 0.05, respectIvely). During early pregnancy DOT decreased serum progesterone levels and changed the protein pattern of uterine secretion. Functional effects, however, were much less expressed compared with the highly significant accumulation of the persistent organochiorines in the genital tract.

Key words: chlorinated hydrocarbons/female rabbit/impaired ovulation/preimplantation period/tissue accumulation

2Present address for correspondence: Department of Anatomy and Cell Biology, Medical Faculty, Martin Luther University, D-06097 Halle/Saale, Germany


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