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Human Reproduction, Vol. 9, No. 5, pp. 781-787, 1994
© 1994 European Society of Human Reproduction and Embryology

research-article

Serum luteinzing hormone pulsatility and intratesticular testosterone and oestradiol concentrations in idiopathic infertile men with high and normal fofficle stimulating hormone serum concentrations

Oscar A. Levalle1,4, Cecilia Zylbersztein2, Sergio Aszpis1, Virginia Mariani2, Roberto Ponzio3, Claudio Aranda1, Abraham Guitelman1 and Hugo E. Scaglia2

1División Endocrinologia, Hospital Carlos G.Durand Diaz Velez 5044, 1406 Buenos Aires 2 Centro de Referencia de Radioinmunoanalisis, La Plata 3Centro de Investigaciones en Reproducción, Cátedra de Histología, Universidad de Buenos Aires Argentina

Correspondence: 4whom correspondence should be addressed

The purpose of the study was to evaluate pulsatile luteinizing hormone (L release and intratesticular concentrations of testosterone and oestradlol in infertile men, to determine if alterations in gonadotrophin secretion are associated with changes in the testicular concentrations of steroids. Patients with idiopathic oligo/azoospermia were divided into a high follicle stimulating hormone (FSH) group (n=5) and a normal FSH group (n = 6). Blood samples were taken every 15 mm for 6 h to determine LH, FSH, testosterone, oestradiol, sex hormone binding globulin, bioactive LH and bioavailable testosterone. The patients underwent a bilateral testicular biopsy for histological assessment and to determine testosterone and oestradiol concentrations. Serum measure ments were compared with those of seven fertile men. The high FSH group had a higher concentration of serum UI and oestradiol than normal men (P < 0.01) and showed a lower frequency of LII pulses than the normal FSH group and control men (P < 0.01). Intratesticular oestradiol was higher in the high FSH group (P < 0.001), with a lower testosterone/oestradlol ratio (P < 0.01). Patients showed a negative correlation between the serum testosterone/LH ratio and FSH (r = -–0.75; P < 0.01) and a positive correlation between the testicular oestradiol concentration and serum FSH (r=0.86; P<0.01). The histopathological examination only showed a smaller tube diameter in the high FSll group (P < 0.05). These data seem to indicate that a higher intratesticular concentration of oestradiol with a lower testosterone/oestradiol ratio in the high FSH group could have a deleterious effect on spermatogenesis.

Key words: gonadotrophin pulsatility/intratesticular steroids/male infertility/testicular biopsy/testicular steroidogenesis


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Home page
 J. Clin. Endocrinol. Metab.Home page
O. Levalle, C. Zylbersztein, S. Aszpis, D. Aquilano, C. Terradas, M. Colombani, C. Aranda, and H. Scaglia
Recombinant Human Follicle-Stimulating Hormone Administration Increases Testosterone Production in Men, Possibly by a Sertoli Cell-Secreted Nonsteroid Factor
J. Clin. Endocrinol. Metab., November 1, 1998; 83(11): 3973 - 3976.
[Abstract] [Full Text]


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