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Human Reproduction, Vol. 9, No. 5, pp. 800-805, 1994
© 1994 European Society of Human Reproduction and Embryology

research-article

Effects of body weight on responses of sernm prolactin to metoclopramide and thyrotrophin-releasing hormone in secondary amenorrhoeic women

M. Takemoto1, H. Morishita, K. Higuchi, J. Yoshida and T. Aono

Department of Obstetrics and Gynaecology, School of Medicine, University of Tokushima 3–18–15 Kuramoto-cho, Tokushima 770, Japan

Correspondence: 1To whom correspondence should be addressed

The present study was designed to Investigate the Influence of body weight on the prolactln responsiveness to metoclopramide and thyrotrophln-releaslng hormone (TRH) in secondary amenorrhoeic women. The responses of serum protactin to metodoprainide and TRH were assessed In relation to body mass index (BMI). Doses of 10 mg of metoclopramide hydrochloride and 500 g of TRH were administered i.v. to 42 secondary ainenorrhoeic women and six women with primary ovarian failure. The increment of serum prolactin at 30 min after the administration of metoclopramide was significantly lower (P < 0.01, respectively) in amenorrhoeic women with a BMI of ≥ 30 or <19 than in amenorrhoeic women with a BMI of 19–24. A significant correlation ratio ({eta}=0.63; P < 0.01) was found between the BMI and the Increment of serum prolactln at 30 min after metoclopramide administration In amenor rhoeic women. The increment of serum prolactin at 15 min after TRH administration was slightly lower in amenorrhoeic women with a BMI of ≥30 or <19 than in amenorrhoeic women with a BMI of 19–24, but these differences were not statistically significant. These results indicate that the body weight Influences the responsiveness of serum prolactln to metoclopramide in secondary amenorrhoeic women.

Key words: body weight/metoclopramide/prolactin response/secondar amenorrhoeic women


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