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Human Reproduction, Vol. 9, No. 7, pp. 1253-1256, 1994
© 1994 European Society of Human Reproduction and Embryology

research-article

Infertility: Expression of heat shock protein 70 kDa in human endometrium of normal and infertile women

M.M.C. Nip1, D. Miller, P.V. Taylor, M.J. Gannon and K.W. Hancock

School of Medicine, University of Leeds Leeds, UK

Correspondence: 1To whom correspondence should be addressed at: Department of Obstetrics & Gynaecology, D floor Clarendon Wing, Belmont Grove, Leeds, LS2 9NS, UK

The expression of heat shock protein (hsp) 70 was investigated in endometrial samples from patients with unexplained infertility associated (n = 5)or not associated (n = 10) with endometriosis, and compared with a control group consisting of fertile women(n = 27) with reported menstrual disturbance. The expression of hsp, and in particular hsp 70, is up-regulated in response to many physico-biochemical insults as well as infection and possibly oncogenic transformation and is a good indicator of a biological system under stress. A significant over-expression of hsp 70 was found in the infertile groups (P < 0.001), suggesting that a stress response may be involved in the aetiology of unexplained infertility irrespective of the presence of endometriosis.

Key words: endometrium/hsp 70/infertility


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M. Ulukus, H. Cakmak, and A. Arici
The Role of Endometrium in Endometriosis
Reproductive Sciences, October 1, 2006; 13(7): 467 - 476.
[Abstract] [PDF]


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