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Human Reproduction, Vol. 9, No. 7, pp. 1289-1292, 1994
© 1994 European Society of Human Reproduction and Embryology

research-article

Andrology: An indiscriminate use of pentoxifylline does not improve in-vitro fertilization in poor fertilizers

Herman Tournaye1, Ronny Janssens, Greta Verheyen, Michel Camus, Paul Devroey and André Van Steirteghem

Centre for Reproductive Medicine, University Hospital, Dutch-speaking Free University (Vrije Universiteit Brussels) Belgium

Correspondence: 1To whom correspondence should be addressed at: Centre for Reproductive Medicine, University Hospital, Vrije Universiteit Brussel, Laarbeeklaan 101, B-1090 Brussels, Belgium

In order to enhance fertilization in vitro, pentoxifylline (PTX) was used in couples showing low fertilization rates in previous in-vitro fertilization (IVF) attempts for the treatment of malefactor infertility. Sibling oocytes were inseminated at random with spermatozoa prepared with or without PTX. After selection by Percoll gradient, sperm samples were divided into two equal aliquots. One aliquot was incubated in Earle's medium containing ~3.6 mM PTX (treatment group), the other aliquot was incubated with PTX-free Earle's medium (control group). After 30 min, both suspensions were washed twice. Sperm parameters after preparation did not differ between treatment and control samples, and nor did the mean fertilization rates, which were 49.3 and 42.6% respectively. Cleavage characteristics and morphological quality of the embryos were not significantly different between the treatment and control groups. The results of this study demonstrate that indiscriminate use of PTX in an IVF programme increases neither fertilization rate nor embryo transfer rate in poor fertilizers. More prospective research is needed to evaluate the role of PTX in IVF in couples selected according to the effect of the compound on sperm function, e.g. hyperactivation and acrosome reaction.

Key words: IVF, male-factor infertility/methylxanthines/pentoxifylline


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