Human Reproduction, Vol. 9, No. 7, pp. 1318-1321, 1994
© 1994 European Society of Human Reproduction and Embryology
research-article |
Fertilization and early embrology: Monozygotic twinning in the human is associated with the zona pellucida architecture
The Center for Reproductive Medicine and Infertility, Cornell University Medical Center–The New York Hospital 505 East 70th Street, HT 330, New York, NY 10021, USA
Correspondence: 1To whom correspondence should be addressed
Six cases of identical twin pregnancies which occurred in 2163 cycles of in-vitro fertilization during a 3 year period are reported. Monozygosity was confirmed when the number of fetuses exceeded the number of embryos replaced (n = 4) or when two concepti were observed in a single amniotic sac (n = 2). Each of the reported pregnancies resulted from replacement of embryos either with naturally thin zonae pellucida or embryos whose zonae had been breached during micromanipulation for assisted fertilization (subzonal sperminsertion) or assisted hatching. That such cases exclusively gave rise to monozygosity suggests a link between the physical state of the zona pellucida, hatching, and generation of identical twins.
Key words: hatching/inner cell mass/micromanipulation/monozygotic twinning/zona pellucida
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  W. Verpoest, L. Van Landuyt, S. Desmyttere, A. Cremers, P. Devroey, and I. Liebaers The incidence of monozygotic twinning following PGD is not increased Hum. Reprod., November 1, 2009; 24(11): 2945 - 2950. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Vitthala, T.A. Gelbaya, D.R. Brison, C.T. Fitzgerald, and L.G. Nardo The risk of monozygotic twins after assisted reproductive technology: a systematic review and meta-analysis Hum. Reprod. Update, January 1, 2009; 15(1): 45 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K I Aston, C M Peterson, and D T Carrell Monozygotic twinning associated with assisted reproductive technologies: a review Reproduction, October 1, 2008; 136(4): 377 - 386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Skiadas, S. A. Missmer, C. B. Benson, R. E. Gee, and C. Racowsky Risk factors associated with pregnancies containing a monochorionic pair following assisted reproductive technologies Hum. Reprod., June 1, 2008; 23(6): 1366 - 1371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q.F. Lyu, L.Q. Wu, Y.P. Li, Q. Pan, D.E. Liu, K. Xia, D.S. Liang, F. Cai, Z.G. Long, H.P. Dai, et al. An improved mechanical technique for assisted hatching Hum. Reprod., June 1, 2005; 20(6): 1619 - 1623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M.R. Gerris Single embryo transfer and IVF/ICSI outcome: a balanced appraisal Hum. Reprod. Update, March 1, 2005; 11(2): 105 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Wright, L. A. Schieve, A. Vahratian, and M. A. Reynolds Monozygotic twinning associated with day 5 embryo transfer in pregnancies conceived after IVF Hum. Reprod., August 1, 2004; 19(8): 1831 - 1836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Moser, T. Ebner, M. Sommergruber, U. Gaisswinkler, K. Jesacher, M. Puchner, R. Wiesinger, and G. Tews Laser-assisted zona pellucida thinning prior to routine ICSI Hum. Reprod., March 1, 2004; 19(3): 573 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Alikani, N. A. Cekleniak, E. Walters, and J. Cohen Monozygotic twinning following assisted conception: an analysis of 81 consecutive cases Hum. Reprod., September 1, 2003; 18(9): 1937 - 1943. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. L. Souter, R. P. Kapur, D. R. Nyholt, K. Skogerboe, D. Myerson, C. C. Ton, K. E. Opheim, T. R. Easterling, L. E. Shields, G. W. Montgomery, et al. A Report of Dizygous Monochorionic Twins N. Engl. J. Med., July 10, 2003; 349(2): 154 - 158. [Full Text] [PDF]
|
|
|
|
|
|
Y. J.R. Menezo and D. Sakkas Monozygotic twinning: is it related to apoptosis in the embryo? Hum. Reprod., January 1, 2002; 17(1): 247 - 248. [Full Text] [PDF]
|
|
|
|
|
|
D.A. Blake, A.S. Forsberg, B.R. Johansson, and M. Wikland Laser zona pellucida thinning--an alternative approach to assisted hatching Hum. Reprod., September 1, 2001; 16(9): 1959 - 1964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schachter, A. Raziel, S. Friedler, D. Strassburger, O. Bern, and R. Ron-El Monozygotic twinning after assisted reproductive techniques: a phenomenon independent of micromanipulation Hum. Reprod., June 1, 2001; 16(6): 1264 - 1269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yakin, S. Kahraman, and S. Comert Three blastocyst stage embryo transfer resulting in a quintuplet pregnancy: Case report Hum. Reprod., April 1, 2001; 16(4): 782 - 784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.T. Mansour, C.A. Rhodes, M.A. Aboulghar, G.I. Serour, and A. Kamal Transfer of zona-free embryos improves outcome in poor prognosis patients: a prospective randomized controlled study Hum. Reprod., May 1, 2000; 15(5): 1061 - 1064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.S. Sills, M. Moomjy, N. Zaninovic, L. L. Veeck, M. McGee, G. D. Palermo, and Z. Rosenwaks Human zona pellucida micromanipulation and monozygotic twinning frequency after IVF Hum. Reprod., April 1, 2000; 15(4): 890 - 895. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Akoum, J. Lavoie, R. Drouin, C. Jolicoeur, A. Lemay, R. Maheux, and E. W. Khandjian Physiological and Cytogenetic Characterization of Immortalized Human Endometriotic Cells Containing Episomal Simian Virus 40 DNA Am. J. Pathol., April 1, 1999; 154(4): 1245 - 1257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Blickstein, H. C. Verhoeven, and L. G. Keith Zygotic Splitting after Assisted Reproduction N. Engl. J. Med., March 4, 1999; 340(9): 738 - 739. [Full Text]
|
|