Skip Navigation

This Article
Right arrow Full Text (PDF )
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Teutsch, G.
Right arrow Articles by Philibert, D.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Teutsch, G.
Right arrow Articles by Philibert, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 9, No. suppl_1, pp. 12-31, 1994
© 1994 European Society of Human Reproduction and Embryology

History and perspectives of antiprogestins from the chemist's point of view

G. Teutsch and D. Philibert

Centre de Recherches Roussel-Uclaf 102 Route de Noisy, 93230–Romainville, France

The discovery of RU486 and its potent activity as an antiglucocorticoid and antiprogestin brought the long story on steroid hormones and antihormones to its logical conclusion. Even though scattered improvements are still possible, the armamentarium of the steroid endocrinologist is by now complete. Like any successful drug, RU486 has become the prototype of a number of analogues which are claimed to be either more active or more dissociated. The literature (mainly patents) has been searched for available data on abortive activities, and some as yet unpublished results on RU compounds have been included. It appears that a number of compounds are both more active than RU486 on a dose basis in animal studies and more dissociated in relation to a possible antiglucocorticoid activity. In addition, hydrosoluble compounds suitable for i.v. injection are available for possible development. In a longer term perspective, It cannot be excluded that potential non-steroidal antiprogestins could present additional advantages over steroidal compounds, in particular improved receptor specificity and/or reduced susceptibility to receptor mutation.

Key words: abortion/antiglucorticoid activity/antiprogestin/pregnancy termination/RU486


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 ReproductionHome page
S. Romero and J. Smitz
Epiregulin can effectively mature isolated cumulus-oocyte complexes, but fails as a substitute for the hCG/epidermal growth factor stimulus on cultured follicles
Reproduction, June 1, 2009; 137(6): 997 - 1005.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
W.-Y. Son, J.-T. Chung, R.-C. Chian, B. Herrero, E. Demirtas, S. Elizur, Y. Gidoni, C. Sylvestre, N. Dean, and S. L. Tan
A 38 h interval between hCG priming and oocyte retrieval increases in vivo and in vitro oocyte maturation rate in programmed IVM cycles
Hum. Reprod., September 1, 2008; 23(9): 2010 - 2016.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.