Skip Navigation

This Article
Right arrow Full Text (PDF )
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kloosterboer, H.J.
Right arrow Articles by Schoonen, W.G.E.J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Kloosterboer, H.J.
Right arrow Articles by Schoonen, W.G.E.J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 9, No. suppl_1, pp. 47-52, 1994
© 1994 European Society of Human Reproduction and Embryology

Pharmacology of two new very selective antiprogestagens: Org 31710 and Org 31806

H.J. Kloosterboer1, G.H. Deckers and W.G.E.J. Schoonen

Organon Scientific Development Group, Department of Endocrinology Oss, The Netherlands

Correspondence: 1To whom correspondence should be addressed at Organon International by, PO Box 20, 5340 BH, Oss, The Netherlands

Org 31710 and Org 31806 are new antiprogestagens. These compounds were tested for their binding affinity to various steroid receptors and for their bio-activity in various animal models and the results were compared with those of RU38486 and ZK 98299. Both Org compounds are strong antiprogestagens with little antiglucocortocoid activity and are devoid of other hormonal activities except for some weak androgenic and anti-androgenic activity. The two compounds are more potent than RU38486 and ZK 98299 with respect to their anti-progestational activity and are more selective. The Org compounds are effective in inhibiting the development of tumours in the 7,12-dimethylbenz(a)anthracene (DMBA) rat model. Org 31710 and Org 31806 may be applied for both the treatment of breast tumours and the improvement of fertility control.

Key words: antiprogestagens/breast tumours/fertility control/Org 31710/Org 31806/RU486/ZK98299


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
P. A. Friberg, D.G. J. Larsson, and H. Billig
Dominant Role of Nuclear Progesterone Receptor in the Control of Rat Periovulatory Granulosa Cell Apoptosis
Biol Reprod, June 1, 2009; 80(6): 1160 - 1167.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
R. Shao, E. Egecioglu, B. Weijdegard, K. Ljungstrom, C. Ling, J. Fernandez-Rodriguez, and H. Billig
Developmental and hormonal regulation of progesterone receptor A-form expression in female mouse lung in vivo: interaction with glucocorticoid receptors.
J. Endocrinol., September 1, 2006; 190(3): 857 - 870.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.