Skip Navigation



Hum. Reprod. Advance Access published online on April 28, 2005
Human Reproduction, doi:10.1093/humrep/deh855
This Article
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
20/7/1903    most recent
deh855v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Tiido, T.
Right arrow Articles by Giwercman, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tiido, T.
Right arrow Articles by Giwercman, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received December 3, 2004
Revised February 10, 2005
Accepted February 22, 2005

Article

Exposure to persistent organochlorine pollutants associates with human sperm Y:X chromosome ratio

Tarmo Tiido 1*, Anna Rignell-Hydbom 2, Bo Jönsson 2, Yvonne Lundberg Giwercman 3, Lars Rylander 2, Lars Hagmar 2, and Aleksander Giwercman 4

1 Fertility Centre, Scanian Andrology Centre, Malmö University Hospital, Lund University, SE 205 02 Malmö, Sweden, and Department of Urology, Malmö University Hospital, Lund University, SE 205 02 Malmö, Sweden
2 Department of Occupational and Environmental Medicine, Lund University Hospital, SE 21885, Lund, Sweden
3 Department of Urology, Malmö University Hospital, Lund University, SE 205 02 Malmö, Sweden
4 Fertility Centre, Scanian Andrology Centre, Malmö University Hospital, Lund University, SE 205 02 Malmö, Sweden, and

* To whom correspondence should be addressed.
Tarmo Tiido, E-mail: Tarmo.Tiido{at}kir.mas.lu.se


  Abstract

BACKGROUND: During the last decades, there has been concern that exposure to endocrine disruptors, such as persistent organochlorine pollutants (POPs), may contribute to sex ratio changes in offspring of exposed populations. METHODS: To investigate whether exposure to 2,2'4,4'5,5'-hexachlorobiphenyl (CB-153) and dichlorodiphenyl dichloroethene (p,p'-DDE) affect Y:X chromosome proportion, semen of 149 Swedish fishermen, aged 27-67 years, was investigated. The men provided semen and blood for analysis of hormone, CB-153 and p,p'-DDE levels. The proportion of Y- and X-chromosome bearing sperm in semen samples was determined by two-colour fluorescence in situ hybridization (FISH) analysis. RESULTS: Log transformed CB-153 as well as log transformed p,p'-DDE variables were both significantly positively associated with Y chromosome fractions (P-values=0.05 and <0.001, respectively). Neither age, smoking nor hormone levels showed any association with Y-chromosome fractions. CONCLUSIONS: This is the first study to indicate that exposure to POPs may increase the proportion of ejaculated Y-bearing spermatozoa. These data add to the growing body of evidence that exposure to POPs may alter the offspring sex ratio.

Keywords: polychlorinated biphenyls; POP; p,p'-DDE; sex ratio; sperm.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
B. Aflatoonian, L. Ruban, M. Jones, R. Aflatoonian, A. Fazeli, and H.D. Moore
In vitro post-meiotic germ cell development from human embryonic stem cells
Hum. Reprod., September 20, 2009; (2009) dep334v1.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
R. M. Steinberg, D. M. Walker, T. E. Juenger, M. J. Woller, and A. C. Gore
Effects of Perinatal Polychlorinated Biphenyls on Adult Female Rat Reproduction: Development, Reproductive Physiology, and Second Generational Effects
Biol Reprod, June 1, 2008; 78(6): 1091 - 1101.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
W. A. Robbins, F. Wei, D. A. Elashoff, G. Wu, L. Xun, and J. Jia
Y:X Sperm Ratio in Boron-Exposed Men
J Androl, January 1, 2008; 29(1): 115 - 121.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
T. Tiido, A. Rignell-Hydbom, B.A.G. Jonsson, L. Rylander, A. Giwercman, and Y.L. Giwercman
Modifying effect of the AR gene trinucleotide repeats and SNPs in the AHR and AHRR genes on the association between persistent organohalogen pollutant exposure and human sperm Y : X ratio
Mol. Hum. Reprod., April 1, 2007; 13(4): 223 - 229.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
B. Aflatoonian and H. Moore
Germ cells from mouse and human embryonic stem cells.
Reproduction, November 1, 2006; 132(5): 699 - 707.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.