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Hum. Reprod. Advance Access published online on June 9, 2005
Human Reproduction, doi:10.1093/humrep/deh888
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received September 30, 2004
Revised February 22, 2005
Accepted March 3, 2005

Article

Exposure to bisphenol A is associated with recurrent miscarriage

Mayumi Sugiura-Ogasawara 1*, Yasuhiko Ozaki 1, Shin-ichi Sonta 2, Tsunehisa Makino 3, and Kaoru Suzumori 1

1 Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya, Japan
2 Department of Genetics, Institute for Developmental Research, Aichi Human Service Center, Japan
3 Department of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa, Japan

* To whom correspondence should be addressed.
Mayumi Sugiura-Ogasawara, E-mail: og.mym{at}med.nagoya-cu.ac.jp


  Abstract

BACKGROUND: Little is known about the influence of high exposure to bisphenol A on recurrent miscarriage and immunoendocrine abnormalities. METHODS: Serum bisphenol A, antiphospholipid antibodies (aPLs), antinuclear antibodies (ANAs), natural killer cell (NK) activity, prolactin, progesterone, thyroid-stimulating hormone (TSH) and free T4 were examined in 45 patients with a history of three or more (3-11) consecutive first-trimester miscarriages and 32 healthy women with no history of live birth and infertility. Subsequent pregnancy outcome and embryonic karyotype of abortuses were examined prospectively. RESULTS: The mean±SD values for bisphenol A in patients were 2.59±5.23ng/ml, significantly higher than the 0.77±0.38ng/ml found for control women (P=0.024). High exposure to bisphenol A was associated with the presence of ANAs but not hypothyroidism, hyperprolactinaemia, luteal phase defects, NK cell activity or aPLs. A high level of bisphenol A in itself did not predict subsequent miscarriage. CONCLUSION: Exposure to bisphenol A is associated with recurrent miscarriage.

Keywords: aneuploidy/antinuclear antibody/bisphenol A/embryonic karyotype/recurrent miscarriage.
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