Hum. Reprod. Advance Access originally published online on May 6, 2008
Human Reproduction 2008 23(7):1553-1559; doi:10.1093/humrep/den122
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Serious primary post-partum hemorrhage, arterial embolization and future fertility: a retrospective study of 46 cases
1 Department of Gynecology–Obstetrics, University Hospital NORD, F-42055 Saint-Etienne Cedex 2, France 2 Laboratoire de Biologie de la Reproduction, Hôpital Nord, Saint-Etienne, France 3 Service de Radiologie, CHU Hôpital Nord, Avenue Albert Raimond, 42055 Saint-Etienne 2, France
4 Correspondence address. Tel: +33-4-77-82-82-87; Fax: +33-4-77-82-81-82; E-mail: celine.chauleur{at}chu-st-etienne.fr
BACKGROUND: The guidelines advise arterial embolization in case of post-partum hemorrhage. We evaluated its feasibility and the subsequent fertility.
METHODS: A retrospective study has been conducted in our center for the past 10 years (1996–2005). Fifty-two patients experiencing a primary post-partum hemorrhage who were resistant to medical treatment underwent uterine artery embolization and/or hysterectomy. In case of arterial embolization, a follow-up of all the patients was realized, focusing on the preservation of fertility.
RESULTS: Six (11.5%) patients underwent hysterectomy straightaway and 46 (88.5%) arterial embolization in the first instance including 35 arterial embolizations after Cesarean section. Embolization was successful among 41 patients (89.1%) and hysterectomy was performed on the 5 (10.9%) others. Overall, 11/24 398 women suffered from a definitive loss of fertility after post-partum hemorrhage. Fertility was studied at least 1 year after the delivery. All patients had a return of normal menses. Sixteen of 41 women (39%) wanted another child and 100% succeeded. Nineteen pregnancies, including two twin pregnancy and one early spontaneous abortion were observed.
CONCLUSIONS: Embolization is a safe and effective non-surgical method to resolve post-partum hemorrhage and should be regarded as gold standard in a hemodynamically stable patient. Furthermore, subsequent fertility is not impaired by the procedure.
Key words: embolization/primary post-partum hemorrhage/Cesarean section/fertility
Submitted on September 12, 2007; resubmitted on March 9, 2008; accepted on March 17, 2008.