Skip Navigation



Hum. Reprod. Advance Access published online on June 21, 2008
Human Reproduction, doi:10.1093/humrep/den231
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
23/12/2813    most recent
den231v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Twisk, M.
Right arrow Articles by Korevaar, J. C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Twisk, M.
Right arrow Articles by Korevaar, J. C
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

No beneficial effect of preimplantation genetic screening in women of advanced maternal age with a high risk for embryonic aneuploidy

Moniek Twisk1,2, Sebastiaan Mastenbroek1, Annemieke Hoek2, Maas-Jan Heineman2, Fulco van der Veen1, Patrick M Bossuyt3, Sjoerd Repping1,4 and Johanna C Korevaar3

1 Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology, Academic Medical Centre, PO Box 22700, 1100 DE Amsterdam, The Netherlands 2 Department of Obstetrics and Gynaecology, University Medical Centre Groningen, Groningen, The Netherlands 3 Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Centre, Amsterdam, The Netherlands

4 Correspondence address. E-mail: s.repping{at}amc.uva.nl

BACKGROUND: Human preimplantation embryos generated through in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatments show a variable rate of numerical chromosome abnormalities or aneuploidies. Preimplantation genetic screening (PGS) has been designed to screen for aneuploidies in high risk patients, with the aim of improving live birth rates in IVF/ICSI. We assessed whether the effect of PGS on live births rates differs in women of advanced maternal age with variable risks for embryonic aneuploidy, and weighed these effects against the results obtained after IVF/ICSI without PGS.

METHODS: The effect of PGS on live birth rates was compared between groups defined by maternal age, number of previous miscarriages, semen quality, total amount of recombinant FSH (rFSH) administered during ovarian stimulation and total number of top-quality embryos, using data from a randomized controlled trial among women of advanced maternal age (35–41 years).

RESULTS: There was no significant differential effect of PGS in groups based on maternal age (P-value of interaction 0.16), the number of previous miscarriages (P-value of interaction 0.93), semen quality (P-value of interaction 0.26), rFSH dose (P-value of interaction 0.15) or the number of top-quality embryos (P-value of interaction 0.59). Live birth rates after IVF/ICSI with PGS were lower in all groups when compared with live birth rates after IVF/ICSI without PGS.

CONCLUSIONS: The paradigm that the effect of PGS is determined by a woman's risk for embryonic aneuploidy seems incorrect. In fact, PGS has no clinical benefit over standard IVF/ICSI in women of advanced maternal age regardless of their risk for embryonic aneuploidy.

Key words: preimplantation genetic screening/in vitro fertilization/aneuploidy

Submitted on February 21, 2008; resubmitted on May 7, 2008; accepted on May 13, 2008.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
E. Vanneste, T. Voet, C. Melotte, S. Debrock, K. Sermon, C. Staessen, I. Liebaers, J.-P. Fryns, T. D'Hooghe, and J. R. Vermeesch
What next for preimplantation genetic screening? High mitotic chromosome instability rate provides the biological basis for the low success rate
Hum. Reprod., November 1, 2009; 24(11): 2679 - 2682.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. R. Hernandez
What next for preimplantation genetic screening? Beyond aneuploidy
Hum. Reprod., July 1, 2009; 24(7): 1538 - 1541.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C.E. Beyer, T. Osianlis, K. Boekel, E. Osborne, L. Rombauts, J. Catt, V. Kralevski, B.S. Aali, and L. Gras
Preimplantation genetic screening outcomes are associated with culture conditions
Hum. Reprod., May 1, 2009; 24(5): 1212 - 1220.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. A. Fritz
Perspectives on the efficacy and indications for preimplantation genetic screening: where are we now?
Hum. Reprod., December 1, 2008; 23(12): 2617 - 2621.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.