Hum. Reprod. Advance Access published online on December 4, 2008
Human Reproduction, doi:10.1093/humrep/den398
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Management of endometriomas in women requiring IVF: to touch or not to touch
1 IVI Madrid, Rey Juan Carlos University, Av. del Talgo 68, Madrid 28023, Spain 2 Infertility Unit, Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy
* Correspondence address. E-mail: jgvelasco{at}ivi.es
The classic, unproven dogma that ovarian endometrioma should be removed in all infertile women prior to IVF has been recently questioned. There is currently insufficient data to clarify whether the endometrioma-related damage to ovarian responsiveness precedes or follows surgery. Both endometrioma-related injury and surgery-mediated damage may be claimed to be involved and the relative importance of these two insults remains to be clarified. Convincing evidence has emerged showing that responsiveness to gonadotrophins after ovarian cystectomy is reduced. Conversely, the impact of surgery on pregnancy rates is unclear since no deleterious effect has been reported. Of relevance here is that surgery exposes women to risk related to a demanding procedure whereas risks associated with expectant management are mostly anecdotal or of doubtful clinical relevance. We recommend proceeding directly to IVF to reduce time to pregnancy, to avoid potential surgical complications and to limit patient costs. Surgery should be envisaged only in presence of large cysts (balancing the threshold to operate with the cyst location within the ovary), or to treat concomitant pain symptoms which are refractory to medical treatments, or when malignancy cannot reliably be ruled out.
Key words: ovarian endometriomas/surgery/IVF/ovarian responsiveness/pregnancy rates
Submitted on July 29, 2008; resubmitted on October 5, 2008; accepted on October 9, 2008.
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