Hum. Reprod. Advance Access published online on April 15, 2009
Human Reproduction, doi:10.1093/humrep/dep085
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Cumulative delivery rates in different age groups after artificial insemination with donor sperm
1 Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, B 1090 Brussels, Belgium 2 Centre for Outcomes Research and Laboratory for Experimental Surgery, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, B 1090 Brussels, Belgium 3 McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4L8 4 Dalhousie University, Halifax, Canada B3H3J5
6 Correspondence address. Tel: +32-2-477-66-99; Fax: +32-2-477-66-49; E-mail: tournaye{at}uzbrussel.be
BACKGROUND: Although the age-effect on in vitro fertilization outcomes has been well documented, data on donor insemination are scarce hampering accurate patient counseling. This cohort study therefore aims at analyzing cumulative delivery rates after donor insemination for various indications.
METHODS: A large retrospective analysis was performed on 6630 insemination cycles in 1654 women. Delivery rates were calculated by life-table analysis after a maximum of 12 cycles in five subgroups of age when starting inseminations. Multivariable modeling was used to explore the effects according to age, indication (male infertility, lesbian couple or single-parent request) and ovarian stimulation protocol (none, clomiphene citrate or gonadotrophins).
RESULTS: Overall, 928 deliveries were observed, i.e. a delivery rate of 14% per cycle and an expected cumulative delivery of 77% after 12 cycles. Subgroup analysis showed an expected cumulative delivery after 12 cycles of 87% for the group aged 20–29, 77% for ages 30–34, 76% for ages 35–37, 66% for ages 38–39 and 52% for ages 40–45. Drop-out analysis in the latter subgroup showed that only one patient discontinued treatment because of medical reasons. In contrast to age, neither indication nor ovarian stimulation protocol had any significant effect on the delivery rate.
CONCLUSIONS: Our study corroborates the impact of age on donor insemination outcome. Nevertheless, even in some older age subgroups, acceptable expected cumulative delivery rates were observed. Despite this, the main reason for discontinuing treatment, however, was the anticipated low success rate. Women, up until 42 years of age, could be encouraged to continue treatment.
Key words: age/donor insemination/cumulative delivery rates/AID/pregnancy
5 Present address: 400 Mader’s Cove Road, RR 1, Mahone Bay, Canada NS B0J 2E0
Submitted on October 16, 2008; resubmitted on March 2, 2009; accepted on March 13, 2009.