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Hum. Reprod. Advance Access originally published online on June 16, 2009
Human Reproduction 2009 24(10):2660-2666; doi:10.1093/humrep/dep208
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Association of polymorphisms –1154G/A and –2578C/A in the vascular endothelial growth factor gene with decreased risk of endometriosis in Chinese women

Qing Liu1, Yan Li2, Jian Zhao2, Dong-Lan Sun2, Ya-Nan Duan2, Na Wang2, Rong-Miao Zhou1 and Shan Kang1,3

1 Department of Obstetrics and Gynaecology, Fourth Affiliated Hospital, Hebei Medical University, Jiankanglu 12, Shijiazhuang, China 2 Department of Molecular Biology, Hebei Cancer Institute, Shijiazhuang, China

3 Correspondence address. Fax: +86-311-86077634; E-mail: ksjq62cn{at}sina.com

BACKGROUND: Vascular endothelial growth factor (VEGF) plays an important role in the development of endometriosis. The aim of this study was to investigate the association of polymorphisms in the VEGF gene with the susceptibility to endometriosis.

METHODS: This study comprised 344 North Chinese women with endometriosis and 360 healthy women without endometriosis recruited as control. Genotyping of the VEGF gene polymorphisms at –460C/T, –1154G/A, –2578C/A and +936C/T were performed by PCR and restriction fragment length polymorphism analysis.

RESULTS: No significant difference was found in allele and genotype distributions of the –460C/T, +936C/T polymorphisms between patients and controls. However, the frequencies of –1154G/A, –2578C/A genotype and allele were significantly different between the two groups (all P-value <0.013). The –2578A/A, –1154A/A genotypes were found less frequently in patients with endometriosis compared with controls. The haplotype distributions derived from three polymorphisms (–2578C/A, –1154G/A, –460C/T) differed between the two groups (P = 0.000).

CONCLUSIONS: The VEGF–460/–1154/–2578 TGC, CAA, TAA and TAC haplotypes were associated with endometriosis. The –1154A and –2578A alleles may be protective against the development of endometriosis in North Chinese women.

Key words: VEGF/endometriosis/polymorphism/gene/susceptibility

Submitted on August 8, 2008; resubmitted on April 2, 2009; accepted on May 14, 2009.


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