Hum. Reprod. Advance Access published online on September 2, 2009
Human Reproduction, doi:10.1093/humrep/dep303
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Determinants of pregnancy rate in the donor oocyte model: a mutivariate analysis of 450 frozen-thawed embryo transfers
1 Service de gynécologie obstétrique et médecine de la reproduction, Hôpital TENON, 4, rue de la Chine 75020, Paris, France 2 Service d'histologie et biologie de la reproduction, Hôpital TENON, 4, rue de la Chine 75020, Paris, France
3 Correspondence address. E-mail: lionel.dessolle{at}tnn.aphp.fr
BACKGROUND: Conflicting results have been published about the determinants of pregnancy after oocyte donation (OD). We used the OD model to determine predictive factors of pregnancy in the recipient after frozen-thawed embryo transfer (FTET) in a specific series where all the embryos were cryopreserved without any prior selection for fresh transfer.
METHODS: We report a retrospective study in a university tertiary care center. Multivariate analysis and logistic regression were used to identify predictive factors of pregnancy in a series of 450 OD FTET cycles in 198 infertile women between January 1992 and December 2006.
RESULTS: The mean (±SD) recipient age was 35.7 (±4.5). Impaired ovarian function was the main indication for OD. The mean ± SD (range) number of embryos transferred was 1.65 ± 0.5 (1–3). Overall clinical pregnancy, implantation and delivery rates were 30, 18 and 23%, respectively. After univariate analysis, pregnancy rates were significantly higher in recipients under 35 years, in women with a body mass index (BMI) <30 kg/m2, in women with an endometrial thickness of 
8 mm, in amenorrheic women and in women not receiving pituitary down-regulation before endometrial preparation. Using multivariate analysis, the BMI, endometrial thickness and the use of pituitary down-regulation were independent predictors of pregnancy, regardless of age.
CONCLUSIONS: This study supports that endometrial thickness of <8 mm, obesity and the use of GnRH analogue pituitary down-regulation before endometrial priming negatively impact pregnancy rates, independently of the recipient's age.
Key words: oocyte donation/frozen embryo transfer/pregnancy rate/implantation rate
Submitted on May 1, 2009; resubmitted on July 25, 2009; accepted on August 5, 2009.