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Human Reproduction, Vol. 14, No. 10, 2423-2426, October 1999
© 1999 European Society of Human Reproduction and Embryology

Debate continued

Antisperm antibodies: Antisperm antibodies and infertility: an unsolvable question?

Tage Hjort

Department of Medical Microbiology and Immunology, Bartholin Building, University of Aarhus, DK-2000 Aarhus, Denmark

Once again the detection and clinical significance of antisperm antibodies (ASA) is being discussed (Helmerhorst et al., 1999Go). Although it is cautiously concluded that `there is reason to accept antibody-mediated antisperm immunity as a cause of subfertility', the authors list three reasons why the clinicians are not inclined to test for ASA in subfertile couples: (i) lack of a standardized and universally accepted assay for ASA; (ii) lack of consensus on the clinical consequences of ASA; and (iii) absence of evidence for a mechanistic explanation on how ASA impair conception. These three claims each deserve a comment.

The discussion by Helmerhorst et al. (1999) is based strictly on modern immunological concepts, leading to the recommendation of immunoblotting and affinity chromatography as promising in this field. For those who have been in the field for many years, these recommendations may provoke a feeling of deja vu. This . . . [Full Text of this Article]

Mechanistic explanations for impairment of conception by ASA?

Lack of a standardized and universally accepted assay for ASA?

Lack of consensus on clinical consequences of ASA?

Notes

References


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