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Human Reproduction, Vol. 14, No. 12, 2927-2929, December 1999
© 1999 European Society of Human Reproduction and Embryology

Debates

Proteomics in reproductive research: The potential importance of proteomics to research in reproduction

Ian A. Brewis1

Department of Molecular Biology and Biotechnology and Department of Obstetrics and Gynaecology (Jessop Hospital for Women), The University of Sheffield, Sheffield, S10 2UH, UK

Recent developments in certain areas of reproductive technology, e.g. intracytoplasmic sperm injection (ICSI), animal cloning and human embryonic stem (ES) cell derivation, have been remarkable and advances are continuing at a considerable rate. However, our understanding of the molecular basis of most aspects of reproduction, particularly in the human, is still extremely poor. This is in marked contrast with the enormous developments in analysis of both genes and their products (proteins) that are currently taking place in the biosciences. For example, microscopic arrays (microarrays) of DNA or oligonucleotides, containing up to several hundred thousand different sequences arranged as individual spots on a `chip', are beginning to be applied to genomic studies and investigations into gene expression (Graves, 1999Go). Over and above this, sequencing programmes of entire genomes are proceeding at a dramatic pace with the Human Genome Project fulfilling its promise as the single most important project in biomedical . . . [Full Text of this Article]

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