Human Reproduction, Vol. 14, No. 6, 1405-1408,
June 1999
© 1999 European Society of Human Reproduction and Embryology
Debate continued |
The benefits of extended culture
Centre for Early Human Development, Institute of Reproduction and Development, Monash University, Level 5, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, Australia, 3168
It is common practice in most human assisted reproduction programmes around the world to carry out embryo transfers on day 2 of culture and, very occasionally, on day 3. However, the need for change has been raised (Tsirigotis, 1998
). Embryos are almost always transferred to the patient's uterus at the early cleavage stage even though, in vivo, the embryo does not normally enter the uterus until the morula stage (Croxatto et al., 1972), which is closer to day 4 of culture. In rodents and domestic ruminants, premature exposure of early cleavage stage embryos to the uterine environment results in the embryos failing to develop further and a poor pregnancy outcome (Moore and Shelton, 1964; Holst and Braden, 1972). However, in both ruminants (Hasler et al., 1987) and mice (Bronson and McLaren, 1970), deferring uterine transfer to the blastocyst stage results in
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