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Human Reproduction, Vol. 14, No. 7, 1669-1671, July 1999
© 1999 European Society of Human Reproduction and Embryology

Debate

Antisperm antibodies

Detection assays for antisperm antibodies: what do they test?

F.M. Helmerhorst1,3, M.J.J. Finken1 and J.J. Erwich2

1 Department of Obstetrics, Gynaecology & Reproductive Medicine, Leiden University Medical Center, PO Box 9600, NL 2300 RC Leiden, and 2 Department of Obstetrics & Gynaecology, University of Groningen, The Netherlands

The lack of a standardized and universally accepted assay for the detection of antisperm antibodies (ASA) which are specifically directed against known antigens, lack of consensus on clinical consequences of ASA (Krapez et al., 1998Go) and absence of evidence for a mechanistic explanation on how ASA impair conception, may be the reasons why physicians are not inclined to test for ASA in subfertile couples.

Balancing pros and cons of ASA testing for our patients has been discussed in a number of reviews (Marshburn and Kutteh, 1994Go; Naz and Menge, 1994Go). The ESHRE Capri Workshop Group (1998) sees `the main reason for testing for antibodies to identify couples who may warrant earlier referral for assisted reproductive technology'. In their excellent paper on unexplained infertility, Taylor and Collins concluded their chapter entitled `antisperm antibody presence and fertility', by commenting that `large prospective studies based on newer validated assay . . . [Full Text of this Article]

Qualitative detection

Quantitative detection

Detection of a specific antigen-antibody bond

Conclusions

Notes

References


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