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Human Reproduction, Vol. 14, No. 7, 1671-1673, July 1999
© 1999 European Society of Human Reproduction and Embryology

Debate

Detection of antisperm antibodies: an argument against therapeutic nihilism

Richard Bronson

Department of Obstetrics and Gynecology, Health Sciences Center, T9-060, State University of New York, Stony Brook, NY 11794-8091, USA

I concur with many of the statements in the first debate (Helmerhorst et al., 1999Go), yet cannot agree with their conclusions that `... it is difficult to consider the routinely used antisperm antibody (ASA) tests as an essential procedure in the fertility work-up nor that it is even more difficult to justify a treatment on the basis of such tests'. As Helmerhorst et al. note, large prospective studies are needed to scientifically prove that ASA cause infertility. We have offered a similar opinion (Bronson and Tung, 1997Go). I believe, however, that this opinion does not justify, on several counts, a recommendation not to routinely test and to treat. Given the low incidence of significant immunities to spermatozoa in men and women (which are found in ~5% of unselected infertile couples), many centres will need to participate in a prospective study of the effects of . . . [Full Text of this Article]

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