Human Reproduction, Vol. 14, No. 9, 2181-2183,
September 1999
© 1999 European Society of Human Reproduction and Embryology
Debate |
Severe OHSS
An `epidemic' of severe OHSS: a price we have to pay?
Department of Obstetrics and Gynecology, Hebrew University Hadassah Medical Center, Ein-Kerem, Jerusalem 12000, Israel
Induction of ovulation by gonadotrophins is one of the major developments in the treatment of infertility in the second half of the 20th century. Today, it is the treatment of choice for >40% of infertile women suffering from ovulatory failure. In addition, extracorporeal fertilization techniques, primarily in-vitro fertilization (IVF) and embryo transfer are used for mechanical problems, male factor, and unexplained infertility, and are practised widely in almost every country in the world today.
Successful induction of ovulation should ideally attain as many follicles and oocytes as possible to obtain the maximal number of embryos in a single treatment cycle. This goal is achieved by using regimens employing gonadotrophin-releasing hormone (GnRH) analogues and high dose gonadotrophins. Unfortunately, these regimens are associated with a serious and potentially life-threatening
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