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Human Reproduction, Vol. 14, No. 9, 2183-2185, September 1999
© 1999 European Society of Human Reproduction and Embryology

Debate

Severe OHSS

Patients should be allowed to weigh the morbidity of OHSS against the benefits of parenthood

R.S. Mathur1 and J.M. Jenkins

Division of Reproductive Medicine, University Department of Obstetrics and Gynaecology, St Michael's Hospital, Southwell treet, Bristol, BS2 8EG, UK

Severe ovarian hyperstimulation syndrome (OHSS) is a potentially life threatening complication of supraphysiological ovarian stimulation. Evidence of an increase in the annual incidence of OHSS and a disproportionate increase in the proportion of severe cases in Israel in the decade beginning January 1987 has been found (Abramov et al., 1999Go). These authors relate this to an increase both in the number of in-vitro fertilization (IVF) cycles performed in Israel over the study period and in the risk of severe OHSS per cycle of IVF. The prevention of OHSS remains a difficult clinical and scientific problem, with no available measure guaranteed to have complete efficacy. In this article, we discuss the difficulties involved in the prevention of OHSS and the need for a wider dissemination of information . . . [Full Text of this Article]

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