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Human Reproduction, Vol. 14, No. 9, 2186-2188, September 1999
© 1999 European Society of Human Reproduction and Embryology

Debate

Spermatid injection

Reconsidering spermatid injection

Y. Prapas1, A. Chatziparasidou2,4, P. Vanderzwalmen3, M. Nijs3, N. Prapas1, B. Lejeune3, G. Vlassis1 and R. Schoysman3

1 Fourth Department of Obstetrics and Gynaecology, Aristoteleian University of Thessaloniki, Thessaloniki, 2 Iakentro, IVF Medical Center, Agiou Vasiliou 4, 54250 Thessaloniki, Greece and 3 SIMAF Van Helmont Hospital, Vilvoorde, Belgium

New developments in the treatment of male infertility offer the possibility for even azoospermic men with impaired spermiogenesis to become biological fathers. The combination of intracytoplasmic sperm injection (ICSI) with techniques such as microepididymal sperm aspiration (MESA), fine needle aspiration (FNA), testicular sperm extraction (TESE) and testicular sperm aspiration (TESA), in most cases yield tiny (but sufficient) spermatozoa to be used on the day of oocyte retrieval. However, there are cases where no spermatozoa can be found, and in these cases, some scientists have attempted spermatid injection based on the data already available in the rodent model (mouse: Ogura et al., 1993, 1994; rabbit: Sofikitis et al., 1994) after it was first suggested (Edwards et al., 1994Go). This new approach has given encouraging results, and has led to fertilization and embryo formation (Vanderzwalmen et al., 1995Go) . . . [Full Text of this Article]

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