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Human Reproduction 2008 23(12):2622-2625; doi:10.1093/humrep/den391
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Preimplantation genetic screening: the end of an affair?

Bart C.J.M. Fauser

Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands

Correspondence address. E-mail: b.c.fauser@umcutrecht.nl

The first 150 words of the full text of this article appear below.

In the human, pregnancy rates per cycle after unprotected intercourse are relatively low. Pregnancy chances drop even further with increasing female age, along with a steep rise in the probability for a spontaneous miscarriage once a pregnancy has been achieved. Most evidence generated so far suggests failed or inadequate implantation due to embryo aneuploidy rather than failed conception as the primary cause of low human fertility (Macklon et al., 2002Go).

In in vitro fertilization (IVF), implantation rates per embryo transferred remain relatively low (Inge et al., 2005Go). Over the years, many efforts have been made to improve embryo culture conditions, to set objective criteria for embryo morphology assessment, and to develop extended embryo culture systems all aiming at improved embryo selection and implantation after transfer to the uterus. Despite all these efforts, pregnancy rates after embryo transfer remain the rate limiting step in IVF, especially in . . . [Full Text of this Article]


   Technical aspects of PGS
 

   The RCT studies
 

   Current conclusions
 

   Where should we go from here?
 

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