Human Reproduction, Vol. 15, No. 6, 1424,
June 2000
© 2000 European Society of Human Reproduction and Embryology
Letters to the Editor |
McGill Reproductive Center Department of Obstetrics & Gynecology, Royal Victoria Hospital, 687 Pine Avenue West F6.58, Montreal, Quebec H3A 1A1, Canada
Dear Sir,
We thank Ranieri and Serhal for their interest in our paper (Gülekli et al., 1999
). We have two points to make in response. (i) The main purpose of our study, as stated in the paper, was to examine the accuracy of the various ovarian reserve tests in predicting the number of follicles within ovaries removed from women of proven fertility. It was not our aim to examine the usefulness of these tests in predicting the response to ovarian stimulation. Many such studies have been performed previously as discussed both in our paper and Ranieri and Serhal's letter. (ii) As regards gonadotrophin-releasing hormone agonist stimulation test (GAST), we used the criteria as described by Winslow, et al. (1991). The test was considered normal for ovarian reserve if the serum oestradiol value on day 3 was double that on day 2. We do not know whether using modified criteria, such as those suggested by Ranieri et al. (1998), would have improved the value of GAST in our study. Again, whilst Ranieri et al.'s study demonstrated that GAST was of use in predicting the response to ovarian stimulation in IVF patients, this was not the intention of our study.
References
Gülekli,B., Bulbul,Y., Onvural, A. et al. (1999) Accuracy of ovarian reserve tests. Hum. Reprod., 14, 2822–2826.
Ranieri, D.M., Quinn, F., Makhlouf, A. et al. (1998) Simultaneous evaluation of basal follicle-stimulating hormone and 17 ß-oestradiol response to gonadotrophin-releasing hormone analogue stimulation: an improved predictor of ovarian reserve. Fertil. Steril., 70, 227–233.[Web of Science][Medline]
Winslow, K.L., Oehninger, S.C., Toner, J.P. et al. (1991) The gonadotrophin-releasing hormone agonist stimulation test—a sensitive predictor of performance in the flare-up in-vitro fertilization cycle. Fertil. Steril., 56, 711–717.[Web of Science][Medline]
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