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Human Reproduction, Vol. 16, No. 11, 2475, November 2001
© 2001 European Society of Human Reproduction and Embryology

Letters to the editor

Semen sample collection in medium and implantation rate following ICSI

E. Van Royen,1 and J. Gerris

Middelheim Hospital, Dept. Ob-gyn-fert., Lindendreef 1,2020 Antwerp, Belgium

Dear Sir,

The paper by Zollner et al. (2001) caught our attention, because it claims that a minor handling step in the sperm collection has an effect on the outcome of ICSI in all oligoasthenoteratozoospermic patients. We were immediately struck by the extremely low P values both for implantation and clinical pregnancy between groups A and B, particularly because both groups were limited in size. Checking the {chi}2 test for a pregnancy rate per transfer of 10/55 (18.2%) in group A versus 16/59 (27.1%) in group B resulted in a non-significant P value of 0.37 which is quite different from the authors' P value of < 0.001. Confidence interval analysis of the same data leads to an OR of 0.597 and a 95% CI of 0.244 to 1.460.

It was not possible to extract the exact number of transferred and implanted embryos from the data in the article. If the mean number of transferred embryos per cycle of 2.67 for all 114 cycles is the same in both groups, we can calculate that of 304 embryos transferred in total, 147 belonged to group A yielding 10 implantations (6.9%) while 157 belonged to group B resulting in 16 implantations (9.9%). {chi}2 test of implantation in both groups produces a non-significant P value of 0.3958, substantially different from the authors' P < 0.0001 (Table II).

We conclude that, on the basis of the data presented by the authors, they cannot make any statistically supported conclusions on the impact of sperm sample collection in medium on the ICSI results in these patients.

Notes

1 To whom correspondence should be addressed Back

References

Zollner, U., Zollner, K.P., Dietl, J. and Steck, T. (2001) Semen sample collection in medium enhances the implantation rate following ICSI in patients with severe oligoasthenoteratozoospermia. Hum. Reprod., 16, 1110–1114.[Abstract/Free Full Text]


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This Article
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