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Correction for Muttukrishna et al., Hum. Reprod. 15 (7) 1640-1645.
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Human Reproduction, Vol. 16, No. 11, 2477, November 2001
© 2001 European Society of Human Reproduction and Embryology

Letters to the editor

Correction to paper published in Human Reproduction: ‘Serum inhibin A and activin A are elevated prior to the onset of pre eclampsia’

S. Muttukrishna1,4, R.A. North2, J. Morris1, J-C. Schellenberg2, R.S. Taylor2, J. Asselin1, W. Ledger1, N. Groome3 and C. Redman1

1 Nuffield Department of Obstetrics and Gynaecology,University of Oxford, John Radcliffe Hospital, Headington,Oxford OX3 9DU, UK, 2 Research Centre for ReproductiveMedicine, Department of Obstetrics and Gynaecology,National Women's Hospital, Auckland, New Zealand and 3 School of Biological and Molecular Sciences, Oxford BrookesUniversity, Headington, Oxford OX3 0BH, UK

Dear Sir,

We wish to report errors in our paper published last year (Muttukrishnaet al., 2000Go). We have recently discovered that the web-based calculator (http://cebm.jr2.ox.ac.uk/docs/2x2table.html) uses an incorrect formula to calculate confidence intervals for sensitivity. We present revised Tables III and IVGoGo below. Confidence intervals were recalculated using the software Confidence Interval Analysis (2000). This resulted in the same point estimates, but wider confidence intervals and minor alterations to post-test probabilities.


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  		Table III. Test characteristics of maternal serum inhibin A and activin A at 15–19 weeks and 21–25 weeks to predict pre-eclampsia (prevalence of 4.8%)
 

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  		Table IV. Test characteristics of maternal serum inhibin A and activin A at 15–19 weeks and 21–25 weeks to predict early onset pre-eclampsia (delivered <34 weeks) with a prevalence of 0.74%
 
We would like to thank Ed Juszczak (Centre for Statistical Medicine, Institute of Health Sciences, Oxford, UK) for his advice and help in reanalysing the data.

Notes

4 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, Royal Free-UCL Medical School, 86–96 Chenies Mews, London WC1E 6HX, UK Back

References

Altman, D.G., Machin, D., Bryant, T.N. and Gardner, M.J.(2000) Statisticswith Confidence. 2nd Edn, BMJ publications, UK.

Muttukrishna, S., North, R.A., Morris, J. et al. (2000) Serum inhibin A and activin A are elevated prior to the onset of pre eclampsia. Hum. Reprod., 15,1640–1645.[Abstract/Free Full Text]


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