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Human Reproduction, Vol. 17, No. 10, 2780, October 2002
© 2002 European Society of Human Reproduction and Embryology

Oxidative stress may have an influence on the effectiveness of IVF

Mohamed A. Bedaiwy, Tommaso Falcone, Jeffrey Goldberg and Rakesh Sharma1

1 Center for Advanced Research in Human Reproduction, Infertility and Sexual Function, Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, A81, Cleveland, Ohio 44195, USA


   Introduction
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 Introduction
References
 
Dear Sir,

We thank Török et al. for their interest in our article (Bedaiwy et al., 2002Go) and their confirmatory data. We fully agree with them that hydrosalpingeal fluid is bad and there is a possible role for oxidative stress in the embryotoxicity of hydrosalpingeal fluid. We have recently demonstrated the effect of vitamin C and E supplementation on blastocyst development in a mouse embryo model after the addition of artificially (phorbol ester) generated reactive oxygen species (ROS). We found that both vitamins C (50 µmol) and E (400 µmol) were able to reverse the embryotoxicity caused by ROS. Vitamin C was more effective in reversing the embryotoxicity (Wang et al., 2001Go, 2002Go). We look forward to their publications and data from other investigators validating the involvement of oxidative stress as one of the underlying cause(s) of hydrosalpingeal fluid embryotoxicity.


   Notes
 
1 To whom correspondence should be addressed: E-mail: sharmar{at}ccf.org Back


   References
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 Introduction
 References
 
Bedaiwy, M., Goldberg, J., Singh, M., Wang, X., Sharma, R.K., Nelson, D. and Falcone, T. (2002) Relationship between oxidative stress and the embryotoxicity of hydrosalpingeal fluid. Hum. Reprod., 17, 601–604.[Abstract/Free Full Text]

Wang, X., Sharma, R.K., Goldberg, J., Attaran, M., Agarwal, A. and Falcone, T. (2001) Vitamin E supplementation reduces oxidative stress and improves blastocyst development rate. Fertil. Steril., 75 (Suppl.), p-40.

Wang, X., Goldberg, J., Attaran, M., Falcone, T., Miller, K. and Sharma, R.K. (2002) Vitamin C and vitamin E supplementation reduces oxidative stress induced embryo toxicity and improves blastocyst development rate. Fertil. Steril., (in press).


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This Article
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