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Human Reproduction, Vol. 17, No. 6, 1671, June 2002
© 2002 European Society of Human Reproduction and Embryology

Confirmation needed for follicular fluid estradiol levels in different ovarian stimulation protocols

Juan A. García-Velasco2 and Antonio Pellicer2

2 IVI–Madrid, C/Santiago de Compostela 88, 28035 Madrid, Spain

Correspondence: E-mail: jgvelasco{at}ivi.es


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 Introduction
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Dear Sir,

We thank Dr Blumenfeld for his interest in our recent publication (Garcia-Velasco et al., 2001Go). Apart from our obvious typographical error (follicular fluid estradiol levels should be in ng/ml and not pg/ml as published), he is concerned about the effect of different starting doses on the final estradiol concentrations. In fact, we mentioned this issue at the end of our discussion as a limitation of the study. However, recent data confirm that both serum and follicular fluid hormone concentrations do not vary when different protocols of FSH are used at similar total doses, but do vary when different GnRH agonist regimens are used (Bo-Abbas et al., 2001Go). Our patients received comparable total FSH doses as shown in Table I. Anyhow, we agree with Dr Blumenfeld that further evidence is needed to confirm our findings.


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Bo-Abbas, Y.Y., Martin, K.A., Liberman, R.F., Cramer, D.W. and Barbieri, R.L. (2001) Serum and follicular fluid hormone levels during in vitro fertilization after short- or long-course treatment with a gonadotropin-releasing hormone agonist. Fertil. Steril., 75, 694–699.[Web of Science][Medline]

García-Velasco, J.A., Isaza, V., Vidal, C., Landazábal, A., Remohí, J., Simón, C. and Pellicer, A. (2001) Human ovarian steroid secretion in vivo: effects of GnRH agonist versus antagonist (cetrorelix). Hum. Reprod., 16, 2533–2539.[Abstract/Free Full Text]


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This Article
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