Table II. Number of children with one or more congenital malformation in the IVF study population and the naturally conceived control population, with corresponding odds ratios (OR)
|
IVF pop.(n = 4224) |
Control pop.(n = 314 605) |
Crude OR(95% CI) |
Corrected ORa(95% CI) |
|
| No. of children with one or more congenital malformations |
137 |
8526 |
1.20 (1.01–1.43) |
1.03 (0.86–1.23) |
| No. of children with one or more minor congenital malformations |
54 |
3445 |
1.17 (0.90–1.54) |
b |
| No. of children with one or more major congenital malformations |
28 |
1700 |
1.23 (0.85–1.79) |
b |
| No. of children with one or more unspecified congenital malformationsc |
55 |
3381 |
1.22 (0.93–1.59) |
b |
|
| aA logistic regression model was used to correct the crude OR for the maternal confounders ‘maternal age’, ‘parity’ and ‘ethnicity’. |
| bCorrection for maternal confounders was not performed since the crude ORs were not significant and the numbers of congenital malformations in the different categories were small. |
| cThese congenital malformations could not be divided into major or minor malformations because they were coded as general non-specific categories of malformations e.g. ‘other congenital malformations of central nervous system’. |
| CI = confidence interval. |
|
