Reply to ‘Reciprocal translocation carriers ascertained for recurrent miscarriage have a possibility to yield an unbalanced fetal chromosome pattern’
Center for Reproductive Medicine, Department of Obstetrics and Gynecology, H4-205, Academic Medical Centerm, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
* Email: m.goddijn{at}amc.uva.nl
Sir,
We thank Mayumi Sugiura-Ogasawara et al. for their comments on our paper (Goddijn et al., 2004
). In this paper, we concluded that karyotyping of 1324 couples ascertained for repeated miscarriage did not yield an unbalanced fetal chromosome pattern after the ascertainment of parental carrier status.
Sugiura-Ogasawara et al., on the other hand, showed that in their Japanese cohort one out of 34 successful pregnancies (2.9%) in carrier couples had an unbalanced translocation (Sugiura-Ogasawara et al., 2004).
If we combine the evidence from the Japanese cohort (1284 couples) with the equal-sized Dutch cohort (1324 couples), regardless of possible differences in cohort composition, only one unbalanced translocation was observed in the live offspring of 2608 couples with repeated miscarriage. In our view, this risk is a very low risk which cannot be compared with the risk of having a chromosomally abnormal fetus in a 43-year-old woman at amniocentesis.
The low risk emphasizes even more the need to find a subgroup with an apparently low frequency of carrier status. We now await the results of a large Dutch multi-centre study to confirm or refute our previous results.
References
Goddijn M, Joosten JHK, Knegt AC, van der Veen F, Franssen MTM, Bonsel GJ and Leschot NJ (2004) Clinical relevance of diagnosing structural chromosome abnormalities in couples with repeated miscarriage. Hum Reprod 19, 1013–1017.
Sugiura-Ogasawara M, Ozaki Y, Sato T, Suzumori N and Suzumori K (2004) Poor prognosis of recurrent aborters with either maternal or paternal reciprocal translocations. Fertil Steril 81, 367–373.[CrossRef][Web of Science][Medline]
Submitted on May 28, 2004; accepted on June 7, 2004.
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