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Hum. Reprod. Advance Access originally published online on February 27, 2008
Human Reproduction 2008 23(5):1236-1237; doi:10.1093/humrep/den054
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© The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

LETTERS TO THE EDITOR

Reply: Sperm chromatin structure assay parameters measured after density gradient centrifugation are not predictive of the outcome of ART

Mona Bungum1,3, Aleksander Giwercman1 and Marcello Spano2

1 Centre of Reproductive Medicine
Malmö University Hospital, Malmö, Sweden 2 Section of Toxicology and Biomedical Sciences
BAS-BIOTEC-MED, ENEA Casaccia Research Center
Rome, Italy

3 Correspondence address. E-mail: mona.bungum{at}med.lu.se

Sir,

We thank Drs Alvarez and Lewis (2008) for their interest in our paper focusing on the predictive value of the Sperm Chromatin Structure Assay (SCSA) on the outcome of ART (Bungum et al., 2008). Their interesting and adequate thoughts contribute to the ongoing scientific debate on the precise nature of human sperm DNA damage and may help in understanding the discrepancies among the variety of tests available to measure sperm DNA strand breaks. Their speculation may also add to clarify why SCSA performed on gradient centrifuged semen was not predictive for the ART outcome. We also agree with them on the requirement of ‘additional studies to evaluate the predictive value of sperm damage levels’ within the framework of more standardized interlaboratory trials.

Reference

Bungum M, Spanó M, Humaidan P, Eleuteri P, Rescia M, Giwercman A. Sperm chromatin structure assay parameters measured after density gradient centrifugation are not predictive of the outcome of ART. Hum Reprod (2008) 23:4–10.[Abstract/Free Full Text]


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This Article
Right arrow Extract Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
23/5/1236    most recent
den054v1
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