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Human Reproduction, Vol. 1, No. 5, pp. 295-297, 1986
© 1986 European Society of Human Reproduction and Embryology

other

Autoimmunity, fetal losses, lupus anticoagulant: beginning of systemic lupus erythematosus or new autoimmune entity with gynaeco-obstetrical expression?

Ph. Edelman1,, A.M. Rouquette2, E. Verdy2, A. Elias3, J. Cabane4, D. Cornet2, J. Barrat4, J. Chavinie5, J. Salat-Baroux2 and Cl. Sureau

Clinique Universitaire Baudelocque 123, Bd de Port Royal, 75014 Paris, France 2Hôpital Tenon 4, rue de la Chine, 75020 Paris, France 3Hôpital Bichat 46, rue Henri Huchard, 75018 Paris, France 4Hôpital St Antoine 184, rue du Faubourg St Antoine, 75012 Paris, France 5Hôpital St Vincent de Paul 74, ave. Denfert Rochereau, 75014 Paris, France

Correspondence: 1To whom correspondence should be addressed

Among the various autoantibodies commonly found in women with systemic lupus erythematosus, the so-called lupus anticoagulant has been described in association with fetal losses. Recently, women with repeated spontaneous abortions and lupus anticoagulant, but no apparent systemic lupus erythematosus have been described. We have studied pro-spectively the possible connections between fetal losses and autoimmunity in a large control study of 130 idiopathic habitual aborters. These non-pregnant patients without any antecedent autoimmune disease were explored for the presence for autoantibodies especially lupus anticoagulant. Ten percent of the patients exhibit an antithromboplastin antibody (lupus anticoagulant) and half of this group possesses a striking association of biological manifestations of autoimmunity. In conclusion, two points appear: firstly, statistical correlation is demonstrated between antithromboplastin antibody and habitual abortion; secondly, doubt remains about the significance of the association between autoimmunity, fetal losses and antithromboplastin: beginning of systemic lupus erythematosus or new autoimmune entity with gynaeco-obstetrical expression.


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