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Human Reproduction, Vol. 10, No. 1, pp. 193-198, 1995
© 1995 European Society of Human Reproduction and Embryology

Epidermal growth factor receptors in human corpora lutea during the menstrual cycle and pregnancy

Firyal S. Khan-Dawood1, Ramchandra R. Ayyagari2 and M.Yusoff Dawood

The Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Medical School at Houston 6431 Fannin, Suite 3.204, Houston, TX 77030 2 Department of Obstetrics and Gynecology, Kern Medical Center Bakersfield, CA, USA

Correspondence: 1To whom correspondence should be addressed

We have demonstrated the presence of epidermal growth factor (EGF) and its receptors in human non-gestational corpora lutea. To determine further the characteristics of EGF receptor binding, we examined 30 human corpora lutea throughout the luteal phase and during pregnancy. Scatchard plots of EGF binding in 29 of the 30 corpora lutea were curvilinear, suggesting negative co-operativity. The mean ± SE of the association constant Ka was (0.9 ± 0.2) x 109 1/mol, the dissociation constant Kd was (2.2 ± 0.3) x10–9 mol/1 and the number of binding sites (Rt) was (15.8 ± 2.1) x10–19 mol/µg protein for non-gestational corpora lutea. The Kd increased significantly in late pregnancies compared to early pregnancies (P = < 0.005), while Rt was significantly higher in term pregnancies than in either early pregnancy (P < 0.01) or the menstrual cycle (P < 0.001). Corpora lutea atretica (n = 2) and ovarian stroma (n = 6) did not show any EGF binding activity. Our findings demonstrate the presence of specific EGF receptors in human corpora lutea of both the menstrual cycle and pregnancy. The changes in EGF binding parameters in early pregnancy suggest that there may be a relationship between the role of EGF and ovarian steroidogenesis.

Key words: corpus luteum/epidermal growth factor/epidermal growth factor receptors/menstrual cycle/pregnancy

Submitted on November 23, 1993; accepted on August 15, 1994.


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