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Human Reproduction, Vol. 10, No. 10, pp. 2700-2704, 1995
© 1995 European Society of Human Reproduction and Embryology

research-article

Relationships between the uterine environment and maternal plasma concentrations of insulin-like growth factor binding protein-1 and placental protein 14 inearly pregnancy

Timothy Wheeler1,2, Timothy Chard3, Frederick Anthony1 and Clive Osmond4

1Department of Obstetrics and Gynaecology, University of Southampton 3Department of Reproductive Physiology, St Bartholomew's Hospital Medical College London, UK 4MRC Environmental Epidemiology Unit Southampton

Correspondence: 2To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, Princess Anne Hospital, Coxford Road, Southampton SO 16 5YA, UK

Blood was obtained from 218 women between 6 and 13 weeks of gestation. Measurements of serum insulin-like growth factor binding protein-1 (IGFBP-1) and placental protein 14 (PP14) concentrations were compared withmaternal weight and height, maternal smoking habit, indices of maternal haematological status and two placental hormones [human chorionic gonadotrophin (HCG) and human placental lactogen (HPL)]. IGFBP-1 concentration was negatively correlated with maternal weight (P < 0.001) and body mass index (P <0.001); PP14 concentration was not correlated with these measurements. PP14 concentration was negatively correlated with maternal haemoglobin concentration (P equals; 0.010), mean corpuscular volume (P equals; 0.003) and serum ferritin concentration (P equals; 0.016). The concentrations of PP14 were significantly less among smokers (P < 0.001); IGFBP-1 concentrations were uninfluenced by smoking. IGFBP-1 concentration was positively correlated with maternal serum HCG (P equals; 0.003) and maternal serum HPL (P equals; 0.002). PP14 concentration was positively correlated with maternal serum HCG (P < 0.0001) but not with HPL. These findings demonstrate that the maternal environment has an early influence on both endometrial and placental function.

Key words: body mass index/haemoglobin/IGFBP-l/PP14/pregnancy/smoking


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