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Human Reproduction, Vol. 10, No. 12, pp. 3110-3116, 1995
© 1995 European Society of Human Reproduction and Embryology

research-article

From basal luteinizing hormone (LH) concentrations to the pre-ovulatory LH surge: titration of the physiological effect of gonadotrophin surge-inhibiting/attenuating factor

J.A.M.J. van Dieten and J.de Koning1

Correspondence: 1To whom correspondence should be addressed

Pulsatile luteinizing hormone (LH) release is thought to be controlled by the functional antagonism between gonadotrophin- releasing hormone (GnRH) and the putative ovarian factor gonadotrophin surge-inhibiting/attenuating factor (GnSIF/AF). Our experiments were designed to titrate the input of endogenous basal and follicle stimulating hormone (FSH)-stimulated GnSIF/AF in this system. The effects were studied of five consecutive pulses of GnRH administration (10-250 pmol/pulse/kg rat), 1 h apart, on the self-priming effect in pro-oestrus phenobarbital-blocked rats injected with FSH or saline. In response to the two high pulses of GnRH, a clear GnRH self-priming was demonstrated. However, pulses of 25 pmol GnRH induced only a minor self-priming effect and the LH blood concentrations were within the physiological range. Pulses of 10 pmol GnRH had no effect. FSH suppressed the unprimed LH response and delayed GnRH self-priming by {small tilde}1 h. Increasing the GnRH pulse frequency of the 25 pmol GnRH pulses from one to three per hour induced pre-ovulatory-like LH surges. The effect was facilitated by ovariectomy to eliminate GnSIF/AF. Thus, the results are consistent with relative inputs of GnRH and GnSIF/AF being responsible for the changes in LH concentration during the ovarian cycle, including the generation of the mid-cycle LH surge.

Key words: functional antagonism/GnSAF/GnSIF/ovarian/factor/self-priming action of GnRH


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