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Human Reproduction, Vol. 10, No. 12, pp. 3121-3123, 1995
© 1995 European Society of Human Reproduction and Embryology

research-article

articles

M. Hignett, J.E.H. Spence1 and P. Claman

University of Ottawa, Ottawa Civic Hospital 1053 Carling Avenue, Ottawa, Ontario, K1Y 4E9, Canada

Correspondence: 1To whom correspondence should be addressed

Thromboembolic events are serious but rare complications following ovarian stimulation for in-vitro fertilization (IVF). We report a case of severe ovarian hyperstimulation syndrome (OHSS), presenting in a second IVF cycle with a late complication of right internal jugular vein thrombosis despite mini-dose heparin prophylaxis. Thrombosis and thromboembolism as late complications of OHSS have been reported by others but not after prophylactic heparinization. The patient was successfully treated with heparin and the twin pregnancy is ongoing. In pregnant patients with severe OHSS consideration should be given to treatment with low dose heparin throughout the first trimester to prevent the serious complications of thrombosis and thromboembolism.

Key words: mini-dose/heparin/prophylaxis/ovarian/hyperstimulation/syndrome/thrombosis


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