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Human Reproduction, Vol. 10, No. 3, pp. 568-571, 1995
© 1995 European Society of Human Reproduction and Embryology

research-article

Infertility: Semi-programmed ovarian stimulation as the first choice in in-vitro fertilization programmes

J.G. Franco, Jr, R.L.R. Baruffi, A.L. Mauri, C.G. Petersen and M.S. Campos

Human Reproduction Center, Sinhá Junqueira Maternity Foundation Ribeirão Preto, São Paulo, Brazil

The objective of this work was to evaluate the results obtained with a protocol of semi-programmed ovarian stimulation (low-dose contraceptive pill + clomiphene citrate + human menopausal gonadotrophin + dexamethasone) used as the first-choice method for in-vitro fertilization (IVF). A total of 207 punctures was performed for oocyte collection from 168 patients (mean age 31.0 ± 4.0 years); mean infertility duration was 5.81 ± 3.30 years. The infertility factors indicating IVF for this population were as follows: tubo-peritoneal factor, 68%; pure or associated male factor, 9.2%; endometriosis, 11.1%; ovulatory factor, 4.3%; idiopathic factor, 11.6%; others, 2.4%. No oocyte was found on aspiration in five procedures (2.4%), with the mean number of oocytes collected per cycle being 5.87 ± 3.3 (range 0–18). The cancellation rate per puncture was 5%. The mean embryo cleavage rate was 60.2 ± 36.8%, with transfer of at least one embryo occurring in 82.6% of all punctures. The mean number of transferred embryos was 2.52 ± 1.60 (range 1–5). The clinical pregnancy rates per started cycle and per puncture were 22.4 (218 ovarian stimulation cycles) and 23.6% (a total of 49 clinical pregnancies, 36 single, nine twins and four triplets) respectively. The clinical pregnancy rate per embryo transfer was 28.6%. The embryo implantation rate was 12.6%. The abortion rate was 16.3%. The index of deliveries per puncture was 19.8%. There were no cases of moderate or severe ovarian hyperstimulation syndrome. The favourable results obtained, in addition to the low operational costs, confirm the validity of the use of semi-programmed cycles as the first choice for patients undergoing the IVF process.

Key words: in-vitro fertilization/ovarian stimulation/semi-programmed cycle


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J.G. Franco Jr, A.M.V.C. Martins, R.L.R. Baruffi, A.L. Mauri, C.G. Petersen, V. Felipe, P. Contart, A. Pontes, and J.B.A. Oliveira
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