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Human Reproduction, Vol. 11, No. 10, pp. 2276-2284, 1996
© 1996 European Society of Human Reproduction and Embryology

research-article

Pregnancy: Effects of a behavioural rhythm on conception probability and pregnancy outcome

Charles E. Boklage

Laboratory of Behavioral and Developmental Genetics, Department of Pediatrics, School of Medicine, East Carolina University Greenville, NC 27858-4354, USA

This paper concerns a behaviour-driven weekday rhythm in conception rates in a large natural human population. From 1978 to 1991, North Carolina normal live single births arose from menstrual cycles which began on Monday in clear excess over other weekdays. Cycles beginning on Friday were also in excess. Cycles starting on Saturday and Sunday, or Wednesday and Thursday, each represented significantly less than one in seven of weekly totals. The source of the observed synchrony was a Sunday morning peak of coital frequency. Average cycles which began on Monday had their most fertile day on the most likely day for intercourse, translating a weekly insemination rhythm into a weekly conception rate rhythm. The secondary conception peak in Friday-onset cycles increased with age, to become the major peak for mothers aged >30 years. We interpret this to represent a previously unreported second type of cycle with a modal follicular phase length of 10 days, the frequency of which increases with age. Several large groups of anomalous human births depart significantly from the weekday rhythm of normal conceptions. These outcomes parallel results of experimental interference with fertilization timing in estruative mammals. We believe that this implicates anomalous fertilization timing in several of the most numerous anomalies of human prenatal development.

Key words: conception/menstrual cycle/oocyte maturation


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