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Human Reproduction, Vol. 11, No. 4, pp. 711-715, 1996
© 1996 European Society of Human Reproduction and Embryology

review-article

Intravenous immunoglobulin treatment of pregnant patients with unexplained recurrent abortions

Arie Raziel2, Arie Herman, Ian Bukovsky, Eliahu Caspi1 and Raphael Ron-el

Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, Sackler School of Medicine Israel 1The Tarnesby-Tarnowski Chair for Family Planning and Fertility Regulation, Tel-Aviv University Israel

Correspondence: 2To whom correspondence should be addressed

Intravenous immunoglobulins, first given to recurrent aborters with anti-phospholipid syndrome, have been administered to unexplained aborters since 1986. They probably have immunomodulatory properties beyond supplying blocking antibodies. When pregnancy was confirmed, women were started with a loading dose which was repeated every 3–4 weeks until the second trimester. Dosages were empirical. Pregnancy rates ranged between 50 and 82%. The main maternal complications, i.e., allergic reactions and infections, were rare.

Key words: habitual abortions/immunotherapy/intravenous immunoglobulins/recurrent abortions/unexplained abortions


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