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Human Reproduction, Vol. 11, No. 4, pp. 722-726, 1996
© 1996 European Society of Human Reproduction and Embryology

research-article

Incidence of chromosome 21 disomy in human spermatozoa as determined by fluorescent in-situ hybridization

J. Blanco, J. Egozcue and F. Vidal1

Unitat de Biologia Cellular, Facultat de Ciències, Universitat Autònoma Barcelona 08193-Bellaterra, Spain

Correspondence: 1To whom correspondence should be addressed

We have evaluated the incidence of chromosome 21 disomy in decondensed sperm heads from nine normal men using a locus-specific DNA probe for chromosome 21, and a centromeric probe for chromosome 6 as a control. The results show that the incidence of chromosome 21 disomy (0.38%) is significantly higher than disomy for chromosome 6 (0.14%). No differences were found among the individuals analysed.

Key words: chromosome 21/disomy/spermatozoa


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