Human Reproduction, Vol 12, 2292-2296, Copyright © 1997 by Oxford University Press
M Sutterlin, S Bussen, D Ruppert and T Steck
We evaluated the folate and cobalamin status in 29 non-pregnant women with
a history of recurrent spontaneous abortion (three or more consecutive) of
unknown aetiology in comparison to 29 healthy nulligravidae of similar
reproductive age (controls). Serum concentrations of folate and cobalamin
showed no significant differences between the two groups. No correlation
between age and vitamin concentrations was found. In the study group there
was a significant negative correlation of the number of previous abortions
and the concentration of serum folate. Patients with at least four previous
miscarriages had significantly lower serum values of folic acid than women
with three abortions, but not than controls. The underlying cause of this
finding remains unclear. In conclusion, the serum concentrations of folic
acid and vitamin B12 are not significantly altered in women with
unexplained recurrent spontaneous abortions, and an association between a
deficiency of these vitamins and an increased risk of pregnancy loss
appears to be questionable in the majority of gestations.
ARTICLES
Serum levels of folate and cobalamin in women with recurrent spontaneous abortion
Department of Obstetrics and Gynecology, University of Wurzburg, Germany.
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