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Human Reproduction, Vol. 12, No. 11, pp. 2393-2398, 1997
© 1997 European Society of Human Reproduction and Embryology

Lymphocytes of human term decidua decrease cell adhesion to a plastic substrate

Ana C. Abadía-Molina1, Concepción Ruiz1, Ashley King2, Y.W. Loke2 and Enrique G. Olivares1,3,4

1 Unidad de Inmunología, Departamento de Bioquímica y Biología Molecular, Facultad de Medicina Spain 2 Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge Cambridge, UK 3 Instituto de Biotecnología, Universidad de Granada Spain

Correspondence: 4To whom correspondence should be addressed at: Unidad de Inmunología, Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Avda. de Madrid 11, 18012 Granada, Spain

Although human decidual lymphocytes have been widely studied, their function and possible interaction with trophoblast are still unclear. Here we show that whereas human early (EDL) and term (TDL) decidual lymphocytes were unable to kill human trophoblast by necrosis (assessed by the 51Cr-release assay) or apoptosis (DNA fragment assay), TDL but not EDL decreased trophoblast adhesion to a plastic substrate as determined by a [3H]thymidine assay. This effect, however, was not selective for trophoblast, as TDL also decreased the adhesion to plastic of human decidual stromal cells and HeLa cells. Our results suggest that TDL may play a role in placental detachment during parturition by decreasing trophoblast or decidual stromal cell adhesion.

Key words: cell adhesion/decidual lymphocytes/parturition/plastic substrate/trophoblast

Submitted on April 24, 1997; accepted on August 12, 1997.


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