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Human Reproduction, Vol. 12, No. 11, pp. 2534-2537, 1997
© 1997 European Society of Human Reproduction and Embryology

Evaluation of maternal plasma creatine kinase activity as a marker of abnormal early pregnancy

Jean-René Zorn1, Brigitte Cherruau, Fady Abi-Rached, Axelle Dehée, Xavier Danoy, Josiane Le Blond and Ohvanesse Ekindjian

Clinique Universitaire Baudelocque et Service de Biochimie A, Hôpital Cochin 75014 Paris, France

Correspondence: 1To whom correspondence should be addressed

We have tested the value of maternal plasma creatine kinase activity for diagnosing ectopic pregnancies obtained after in-vitro fertilization and embryo transfer. Plasma creatine kinase was assayed in 57 patients: 20 normal, 23 miscarriages and 14 ectopic pregnancies, for a total of 240 samples. All values were in the lower part of the normal range except only one in a miscarrying patient. A statistically significant difference was observed for a cut-off value of 45 IU/l between normal and ectopic pregnancies. However, for this cut-off point, the measurement of plasma creatine kinase activity had a sensitivity of 0.50 and a specificity of 0.76 for the diagnosis of ectopic pregnancy. The positive predictive value was 0.69. Creatine kinase activity measurements are thus of no practical value in this particular population, in which an early and specific marker of ectopic implantation would be of paramount interest. The association of human chorionic gonadotrophin (HCG) determinations and ultrasound scanning of the pelvis still remain the best paraclinical support for an early diagnosis of ectopic implantation.

Key words: creatine kinase/ectopic pregnancy/in-vitro fertilization

Submitted on February 2, 1996; accepted on August 13, 1997.


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