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Human Reproduction, Vol. 12, No. 11, pp. 2553-2556, 1997
© 1997 European Society of Human Reproduction and Embryology

Case Report: Pregnancy with concomitant chorangioma and placental vascular malformation with mesenchymal hyperplasia

Chih-Ping Chen1,2,4, Schu-Rern Chern2, Tao-Yeuan Wang3, Zon-Darr Huang2, Ming-Chao Huang1 and Chun-Yu Chuang2

1 Department of Obstetrics and Gynecology 92, Section 2, Chung-Shan North Road, Taipei, Taiwan, Republic of China 2 Department of Medical Research 92, Section 2, Chung-Shan North Road, Taipei, Taiwan, Republic of China 3 Department of Pathology, Mackay Memorial Hospital 92, Section 2, Chung-Shan North Road, Taipei, Taiwan, Republic of China

Correspondence: 4To whom correspondence should be addressed

We present two pregnancies associated with normal live births and the unusual concomitance of chorangioma and placental vascular malformation with mesenchymal hyperplasia. The enlarged placenta had the characteristic findings of chorangioma, dilated and varicose chorionic vessels and multiple vesicle-like villi containing hyaluronic acid. The vesicle-like villi showed diploid cellular DNA contents. Molecular genetic analysis using the polymerase chain reaction amplification of polymorphic microsatellite markers confirmed genetic identity among the chorangioma, the vesicle-like villi and the fetus. Both pregnancies were complicated by polyhydramnios, preterm labour and prematurity. One neonate suffered from anaemia and thrombocytopenia. Another neonate suffered from haemangiomatosis. Our cases demonstrate that concomitant chorangioma and placental mesenchymal hyperplasia are genetically identical to the fetus and can coexist with a normal viable fetus. Since haemangiomas, chorangiomas, chorionic vessels and villi mesenchymal cells are all derived from the mesoderm, a combination of fetal haemangiomas, placental vascular malformation, chorangiomas and placental mesenchymal hyperplasia may represent a mixed form of congenital malformation of the mesoderm.

Key words: chorangioma/haemangioma/mesoderm/placental mesenchymal hyperplasia/placental vascular malformation

Submitted on June 19, 1997; accepted on August 4, 1997.


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